Georgi’s Blog

Добри новини за диабетици

Списание Клетка ( едно от трите най-добри списания по науки ) е публикувало наскоро статия на тема контрол на диабет и възстановяване на продукция на инсулин ( може и да не е точно така, ама е доста медицинско и не мога точно да си го преведа. Ако някой може да се обажда ). Накратко тези учени са успели да намалят прогреса на диабет и да възстановят чувствителността на панкреаса. Очаква се до година две да има лекарство за хора.

SUMMARY
In type 1 diabetes, T cell-mediated death of
pancreatic b cells produces insulin deficiency.
However, what attracts or restricts broadly
autoreactive lymphocyte pools to the pancreas
remains unclear. We report that TRPV1+ pancre-
atic sensory neurons control islet inflammation
and insulin resistance. Eliminating these neu-
rons in diabetes-prone NOD mice prevents
insulitis and diabetes, despite systemic persis-
tence of pathogenic T cell pools. Insulin resis-
tance and b cell stress of prediabetic NOD
mice are prevented when TRPV1+ neurons are
eliminated. TRPV1NOD, localized to the Idd4.1
diabetes-risk locus, is a hypofunctional mutant,
mediating depressed neurogenic inflammation.
Delivering the neuropeptide substance P by
intra-arterial injection into the NOD pancreas
reverses abnormal insulin resistance, insulitis,
and diabetes for weeks. Concordantly, insulin
sensitivity is enhanced in trpv1 mice, whereas
insulitis/diabetes-resistant NODxB6Idd4-con-
genic mice, carrying wild-type TRPV1, show re-
stored TRPV1 function and insulin sensitivity.
Our data uncover a fundamental role for insulin-
responsive TRPV1+ sensory neurons in b cell
function and diabetes pathoetiology

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