We have arrived in Bulgaria alive. Only one bag is missing and we were delayed only 3-4 hours. I need to have some sleep. Tomorrow for more…

Cell magazine ( one of the top three science magazines ) has published an article called “TRPV1+ Sensory Neurons Control b Cell Stress and Islet Inflammation in Autoimmune Diabetes”. In few words they are able to reduce diabetic progress and recover insulin production. It is expected in an year or two to have a cure for diabetes.

SUMMARY
In type 1 diabetes, T cell-mediated death of
pancreatic b cells produces insulin deficiency.
However, what attracts or restricts broadly
autoreactive lymphocyte pools to the pancreas
remains unclear. We report that TRPV1+ pancre-
atic sensory neurons control islet inflammation
and insulin resistance. Eliminating these neu-
rons in diabetes-prone NOD mice prevents
insulitis and diabetes, despite systemic persis-
tence of pathogenic T cell pools. Insulin resis-
tance and b cell stress of prediabetic NOD
mice are prevented when TRPV1+ neurons are
eliminated. TRPV1NOD, localized to the Idd4.1
diabetes-risk locus, is a hypofunctional mutant,
mediating depressed neurogenic inflammation.
Delivering the neuropeptide substance P by
intra-arterial injection into the NOD pancreas
reverses abnormal insulin resistance, insulitis,
and diabetes for weeks. Concordantly, insulin
sensitivity is enhanced in trpv1 mice, whereas
insulitis/diabetes-resistant NODxB6Idd4-con-
genic mice, carrying wild-type TRPV1, show re-
stored TRPV1 function and insulin sensitivity.
Our data uncover a fundamental role for insulin-
responsive TRPV1+ sensory neurons in b cell
function and diabetes pathoetiology

link

This Friday adobe released the first beta of Phosothop. The best news for us Mac users is that it is now unibin. Here is the difference:
Radial Blur with 100 on Best and spin

Using this image:

http://joro.geodar.com/images/ps3.jpg

Photoshop CS2: 103 seconds
Photoshop CS3: 70 seconds

MacBook 2.0GBz white, 1.25GB ram, 100GB hdd 5400rpm

The plan is to fly away from New York this comming Tuesday and to arrive in Sofia the next day. But before that, I have to go to work today, tomorrow I have to get our i-20s signed, to pay part of my school bill, to prepare the luggage, to go to my last final for the semester and if everything is allright on Wednesday be in Plovdiv renting a nice place! Why rent? I’ll write about that when I go home. That’s enough for now